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Oral administration forces any compound to travel through the gastrointestinal tract, be absorbed across the intestinal epithelium, and then pass directly to the liver via the hepatic portal vein before reaching the rest of the body

If the diagnosis of neuropsychological manifestations of vitamin B12 deficiency is delayed, symptoms may become irreversible [7,8,9] within variable time intervals (months to years), depending on residual B12 stores in the liver

Mov Disord 27:720726 Priano L, Bigoni M, Albani G, Sellitti L, Giacomotti E, Picconi R, Cremascoli R, Zibetti M, Lopiano L, Mauro A (2019) Sleep microstructure in Parkinsons disease: cycling alternating pattern (CAP) as a sensitive marker of early NREM sleep instability

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