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However, antigen sampling of luminal microbes is necessary for immunological development, bacterial clearance and the production of IgA, the latter of which is important in restricting microbial adhesion to the mucosal layer and coating commensal species to limit their interaction with immune system (Johansen et al

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However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia (Riemann et al., 2020