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One way is from the essential amino acid tryptophan

The percentage of infants with vitamin B 12 deficiency was 26% in those born to supplemented mothers, which was significantly lower than the 31% to 37% reported in those not given a vitamin B 12 supplement

Vitamin B12 plays a crucial role in: Red blood cell production Brain and nerve function DNA synthesis Energy metabolism A deficiency can lead to symptoms like: Fatigue and weakness Poor concentration or memory Pins and needles Pale skin Low mood or irritability If left untreated, long-term deficiency can cause nerve damage and other health issues

The magnitude and reproducibility of these changes align with the expected biochemical consequences of CD38 engagement by DARA and ISA and remain biologically meaningful within the context of purinergic remodeling