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By weeks three to five, skin darkening becomes more noticeable, especially if combined with moderate sun exposure

The clinical presentation of DM is often non-specific with lesions showing local growth, a palpable nodule or plaque, and an absence of pigmentation in about 60% of cases [14], especially in the pure type (with prominent fibrosis)

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Although the pretest probability was low, the morbidity from undiagnosed B12 deficiency is high, warranting a trial of B12 supplementation that resolved the patients symptoms. Cracks at the Corners of the Mouth and Pernicious Anemia: I would like to tell you that there is a lot of research linking angular cheilitis to nutritional deficiencies