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However, serious undesirable side effects, including cardiovascular events, nephrotoxicity, osteonecrosis of the jaw, atypical fractures and gastrointestinal distress, are becoming increasingly prominent, limiting their long-term use (Patel et al., 2018)

Wang Z, Gao J, Li D et al (2020d) Co-occurrence of microplastics and triclosan inhibited nitrification function and enriched antibiotic resistance genes in nitrifying sludge

doi: 10.3389/fimmu.2025.1666233 Received 15 July 2025 Accepted 29 September 2025 Published 15 October 2025 Volume 16 - 2025 Edited by Tara Marlene Strutt, University of Central Florida, United States Reviewed by Huang Huang, Fudan University, China Xiao-Yong Man, Zhejiang University, China Updates Copyright 2025 Xu, Guo, Xu, Chen, Chen and Xu

Cytosolic phosphoenolpyruvate carboxykinase (PCK1) catalyzes oxaloacetate-to-glucose-6-phosphate conversion, diverting metabolic flux toward glycogen synthesis and PPP activation