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Ethics statement Skin biopsy samples used in this manuscript and animal experiments were approved by the local ethics committee and the institutional review board of Huashan Hospital and conducted in accordance with the Helsinki declaration

The Y- and radial arm mazes were used to assess and score spatial working memory as previously described[54,55]

Internalized CIRP effectively blocks the interaction between ZBP1 and tripartite motif-containing 32 (TRIM32), an E3 ubiquitin ligase targeting ZBP1 for proteasomal degradation, thereby enhancing ZBP1-dependent PANoptosis of PVECs and exacerbating ALI in sepsis

It's crucial to understand that the exact dosage can vary based on individual health profiles and the discretion of healthcare providers