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Furthermore, CHS was associated with upregulated expression of cytoprotective anti-oxidative metabolites (itaconate, glutamine, N-acetyl glutamine) as well as decreased perfusate protein levels of pro-inflammatory cytokines and cell-free mitochondrial DNA (mtDNA) (Figure 5) [ FIGURE 5 In a porcine model of orthotopic left LTx, Abdelnour-Berchtold et al