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FIGURE 2 6 Conclusion and future perspectives Therapeutic approaches to address oxidative stress typically involve upregulating antioxidant signals such as NRF2, administering exogenous antioxidants, supplementing trace elements or nutrients, and implementing environmental interventions ( de novo GSH synthesis but also exhibits independent antioxidant effects

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These approaches can be divided into three major categories: (i) invasive approaches, (ii) minimally invasive approaches, and (iii) non-invasive approaches

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