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J Clin Invest 125 , 15911602, (2015)

3,4 This diagnostic challenge underscores the urgent need for novel biomarkers

Studies have demonstrated that cigarette smoking exerts both direct and indirect effects on the gastrointestinal tract, encompassing oxidative damage, compromised immune cell functionality, alterations in epigenetic patterns, as well as changes in microbial composition that collectively contribute to intestinal barrier dysfunction (Papoutsopoulou et al., 2020)

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