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Introduction Autoimmune diseases affect an estimated 15 million individuals in the United States and represent a significant burden of chronic morbidity ( Autoimmune diseases are widely recognized as multifactorial, arising from a complex interplay of genetic predisposition, environmental triggers, and immune dysregulation ( Sex-based differences represent one of the most consistent and striking features of autoimmune disease epidemiology, with female accounting for nearly 80% of all cases ( Environmental exposures also play a pivotal role in triggering or modulating autoimmune responses