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Meanwhile, taurine also increases insulin secretion by increasing extracellular glucose concentration through the glucose transporter GLUT-2 in cells (115)

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Previous studies in rats and human subjects have shown that not the activity of -butyrobetaine dioxygenase but the availability of carnitine precursors, particularly -butyrobetaine, for the enzymatic reaction is rate limiting for carnitine biosynthesis ( Reference Rebouche, Bosch and Chenard 80 , Reference Rebouche, Lehman and Olson 81 )

Compared to the placebo group, patients who took 3 g of immediate-release nicotinic acid daily experienced an average 10% reduction in total blood cholesterol, a 26% decrease in triglycerides, a 27% reduction in recurrent nonfatal myocardial infarction, and a 26% reduction in cerebrovascular events (stroke and transient ischemic attacks)