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Description

Interestingly, elevated pyroglutamate levels have been associated with toxic effects 37 , as its accumulation may disrupt redox homeostasis and interfere with glutamate metabolism

10.24018/ejdent.2021.2.1.37 36

The use of objective neurophysiological measures (e.g., EEG, MRI, MEG, ABR) or biomarkers (e.g., blood or DNA sampling) may be more useful and reduce experimental variability