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The active areas of cholinesterase enzymes contain critical amino acids that could be used in the development of effective drugs

doi: 10.3389/fnins.2026.1780573 Received 04 January 2026 Revised 04 February 2026 Accepted 09 February 2026 Published 20 February 2026 Volume 20 - 2026 Edited by Frank Hirth, King's College London, United Kingdom Reviewed by Rajalakshmi Ramamoorthy, University of Miami, United States Salvador Soriano, Loma Linda University, United States Updates Copyright 2026 Wang, Zhang and Guo

& Gautreau, A

Reduced BDNF levels can impair the signaling pathways that promote cell survival and synaptic plasticity, further contributing to the loss of neuronal integrity (Peregud et al