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ADVERSE EFFECTS The major adverse effect associated with warfarin use is bleeding, including fatal intracranial and gastrointestinal (GI) hemorrhages

Holmgren, 1978

The National Cancer Institute (NCI) designed the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) to gauge clinical adverse events (AEs) directly from the patients participating in cancer clinical trials ( RISRAS (radiation-induced skin reaction assessment scale) The RISRAS is a comprehensive grading scale (scoring between 0 to 36) integrating both the clinician-based and patient reported outcomes, especially devised to evaluate the skin symptoms related with radiation dermatitis ( Table 1

Therefore, ALA is usually only considered in pregnancy if the potential benefit clearly outweighs any theoretical risk, and only under close medical supervision