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Inhibition of NOS by L-NAME resulted in further enhancement of LTE4 synthesis in BAECs exposed to the arsenic/Mn mixture, indicating that this additive effect involves a complex interplay between oxidative stress and NO pathways [117]

Subsequent studies, including two randomized trials, have shown that adding HCQ to the gemcitabine/nab-paclitaxel treatment regimen can improve response rates [100, 101]