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doi: 10.1016/j.mehy.2020.109862 220 PoljsakB.uputD.MilisavI

This phenomenon underpins a central mechanism of treatment resistance: anti-PD monotherapy may confer compensatory upregulation of other checkpoint molecules (e.g., LAG-3 and Tim-3) on T cells, thereby amplifying localized T-cell suppression [252, 253]