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The minus-end-directed dynein drives retrograde transport, while the plus-end-directed kinesin (mainly KIF5) controls anterograde transport

As the primary protein constituent of chromatin, forming complexes with DNA to compact our large genome for efficient nuclear organization, histones support critical cellular processes such as transcription, DNA replication, and DNA repair through diverse post-translational modifications that regulate their interactions with DNA and other nuclear proteins

10.1038/cdd.2010.191 Cell Death Differ

If a woman experiences no benefits after that time, the medication is not going to work for her and it can be discontinued