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Through the upregulation of intestinal Nrf2 and HO-1 expression, vinpocetine dramatically reduced oxidative stress damage

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On one hand, its multi-target therapeutic potential lacks validation through large-scale, randomized, double-blind, placebo-controlled clinical trials in humans, which hinders the effective translation of preclinical findings into clinical applications

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24,28 Age-related inhibition of cellular growth and function, a process known as senescence, is also believed to play a role

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5-Fluorouracil neurotoxicity in a patient with normal dihydropyrimidine dehydrogenase activity

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