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Therefore, astrocytes have emerged as a key component of the CNS vascular system, where they regulate the transfer of metabolites from the blood, communicate with the peripheral immune system, maintain the integrity of BBB, regulate homeostasis, and initiate blood vessel contractility phenomenon upon a neuronal activity (Cohen-Salmon et al., 2021)

10.1002/mds.24962 Mov

Although PPAR, a key transcriptional regulator of adipogenesis and lipid metabolism, showed only a modest increase in EiaKO BAT, the elevated levels of its downstream target FABP4 suggested a compensatory response to lipid overload resulting from impaired mitochondrial fatty acid utilization (Fig

Nausea, somnolence, dizziness, constipation, and loss of appetite have been reported as common side effects of duloxetine and venlafaxine, but they are considered relatively safe drugs to use [46,49]