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Resistant hypertension (assuming adherence checked and confirmed) Non-adherent patients (considering the extreme pill dysutility - bordering on pill hatred - in some patients) Renal denervation potentially provides a smoother BP lowering, unlike the vagaries of troughs and peaks, heightened by the occasional missed dose, with pharmacotherapy - does this justify using renal denervation more widely

Main research area: Alzheimer's disease and dementia Key Validation Experiment: In mouse models, when the HGF pathway was blocked using an antagonist, the cognitive improvement effect of Dihexa disappeared, proving that its action is indeed specific

doi: 10.1016/j.redox.2023.102691 12

10.1038/s41419-019-1364-0 95 LiM