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Lipid peroxidation is initiated by a radical attack such as OH or HO2 radicals, which remove the bis-allylic hydrogen from the PUFA chain and generate a carbon-centered lipid radical or alkyl radical (PL-PUFA )

Given that STING protein resides in the ER, where SCAP/SREBP sense cholesterol, it is likely that STING signaling is activated in response to decreased cholesterol levels in the ER membrane

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