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First, some studies indicate that L-glutamine supplements alter the composition of your gut microbiome, which is the community of beneficial bacteria in your digestive tract ( The gut microbiome plays a central role in many aspects of health, including weight management ( Whats more, glutamine may protect against inflammation, which is linked to many chronic conditions, including obesity ( Finally, while studies show that L-glutamine may improve blood sugar control, theres conflicting evidence on whether it affects insulin the hormone responsible for transporting sugar from your bloodstream into your cells ( However, some human and animal studies suggest that glutamine enhances insulin sensitivity, improving your bodys ability to use insulin efficiently