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For instance, up-regulated Tregs cells in the TME induce DNA damage in CD4(+) T and CD8(+) T cells and overexpress senescence-associated -galactosidase (SA--Gal), promoting cell cycle progression and growth arrest in the G0/G1 phase, leading to T cells senescence and impaired tumour immunosuppressive capacities, which are co-regulated by MAPK and STAT1/STAT3 signaling pathways (226)

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Energy Metabolism: NAD+ is a key player in cellular respiration, which is the process by which cells convert nutrients into energy