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High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase

MMP-2 has been shown to have a role in synaptic plasticity (66) and be upregulated by noradrenaline (67)two biological mechanisms implicated in PTSD

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Several therapeutic strategies targeting either the primary or secondary defects of FRDA are under development following two main directions: (1) restoration of FXN levels using gene expression modulators, protein stabilizers and gene therapy and (2) alleviation of secondary cellular defects such as mitochondrial functions, iron accumulation, oxidative stress and ferroptosis (Zesiewicz et al., 2020