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The proposed IPQ method builds upon the strengths of the original PQ approach 10 , which is conceptually simple and efficient in detecting model misfit at any level of a hierarchical model without additional computational costs

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Volatiles were then removed under reduced pressure and the crude residue was purified by chromatography on silica gel (DCM/MeOH gradient from 100:0 to 90:10) to quantitatively afford the first intermediate tert-butyl (2-(4-((S)-2-((((9H-fluoren-9- yl)methoxy)carbonyl)amino)propanamido)phenyl)-2-hydroxyethyl)carbamate that was directly engaged in Fmoc-deprotection

Another garlic bioactive that exhibits antiproliferative properties is Ajoene