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Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]

While the adverse events heterogeneity could be attributed to one particularly sensitive study, the remaining variability likely stems from methodological differences in study design, participant characteristics, and curcumin formulations (including bioavailability-enhancing technologies)

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