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Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knock in mouse model of Alzheimers disease

Selenium Selenium is an essential trace mineral that supports antioxidant defense, boosts immune function, and plays a key role in thyroid hormone metabolism, helping to protect the body from oxidative stress and promote overall health

We then expressed these proteins in HEK293T cells to determine their effect on autophagy by detecting the protein levels of SQSTM1/p62 (a substrate receptor degraded by autophagy) and LC3-II (autophagosome membrane marker protein degraded through autophagy)

doi:10.1126/science.1210858