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For example, etesevimab, an anti-SARS-CoV-2 mAb developed by Eli Lilly that has received an EUA for COVID-19, has been engineered to lack FcRI and FcRII-binding activity with L234A and L235A mutations (the LALA modification) 74 in the Fc domain to reduce safety concerns over the potential to exacerbate disease through ADE mechanisms 75

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In both cellular and mouse models, the derivative dihydroartemisinin successfully suppressed tumor progression and vasculogenic mimicry formation (77)