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A deeper understanding of the mechanisms of ROS interactions originating from different sources, such as mitochondria and NADPH oxidase, may open new avenues for therapeutic interventions in angiogenesis-related cancer and other chronic diseases

Nat Rev Clin Oncol (2017) 14:20320

239 The body increases thermogenesis, primarily through non-shivering thermogenesis in brown adipose tissue, which involves increased FAO and uncoupling of OXPHOS to generate heat rather than ATP