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Consistently, SOD1 G93A transgenic mice exhibited ferroptotic features and neurotoxic glial activation resembling those observed in ALS patient spinal cords and in vitro models

Elevated GLS expression is also associated with different cancer types, including glioblastoma and pancreatic cancers, thereby encouraging investigation of more targets should current clinical trials prove successful [28, 61]

doi: 10.1016/j.ejmg.2013.10.002

We found that treatment of sagittal brain slices with 1 mM CPZ alone induced demyelination of the corpus callosum, reducing MBP expression to ~51% and MOG expression to ~53% of untreated slices, 24 h post-treatment