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ul-Huda N, Richardson, BM, Ware C, Camus A, Older CE, Yamamoto F, Goodman P, Riefers G, Wise DJ, Marancik D, Griffin MJ (2023)

In a controlled, open trial with psoriasis patients, secukinumab did not cause liver enzyme elevations, while methotrexate led to a threefold increase in liver enzymes in 4 of 64 patients, necessitating withdrawal (Gisondi et al

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Most of the gene-expression evidence is based on microarray and bioinformatics, not a demonstration that tired cells were actually rescued