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This balance between MCU-mediated calcium influx and NCLX-mediated efflux is critical in maintaining mitochondrial integrity and preventing calcium-induced mitochondrial dysfunction (41)

Consistent with the evidenced counteraction of the increased pressure in the superior sagittal sinus, portal and caval hypertension, and the counteraction of the additional venous hypertension, either originated centrally (inside the sinus lumen) or peripherally (into the neck or abdomen), venography in all BPC 157 rats reveals activated collaterals presentation

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Together, they create a synergistic biological response that optimizes healing from all angles