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Tetramethylpyrazine is the main active ingredient of Rhizoma Ligustici Chuanxiong, a Chinese herbal that has long been used to treat liver disease and protect the liver from fibrosis (115, 116)

Modulating tumor hypoxia by nanomedicine for effective cancer therapy

We adjust the schedule based on the patients condition and how they respond to therapy

There is, also in this case, a retrograde signaling, from the mitochondria to the nucleus, which pushes the latter to trigger the synthesis of AOX (Figure 12)