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These observations are consistent with the relative affinities of the sensor variants determined in vitro ( Figure 1 ) and suggest robust and active maintenance of NADP redox state even under severe oxidative challenge, which is in stark contrast to previous observations of a highly volatile cytosolic NAD redox state as monitored by Peredox [13, 23]

Such strategies that disrupt key regulatory signals highlight the potential to modulate CAF activity and reprogram the tumor stroma

Vitamin B12 is typically derived from animal products, which can make it challenging to find for those living a vegan lifestyle