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10 There are several distinct patterns (Figure 2), including: 14 centrofacial located on the cheeks, nose, forehead and upper lip (excluding the philtrum) and is present in approximately 5080% of cases malar located over the nose and malar cheeks mandibular pattern located over the mandible and chin extrafacial this pattern is variable, but is predominantly located on the upper extremities, often on sun-exposed sites

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Furthermore, iron overload has been shown to exacerbate disc degeneration, ultimately contributing to herniation

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