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Circulation 117:915922 Dokun AO, Chen L, Lanjewar SS, Lye RJ, Annex BH (2014) Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD

Reusing needles may cause them to become dull or bent, increasing discomfort and infection risk while potentially affecting insulin delivery accuracy

I mention the arithmetic first because everyone else leads with the mechanism, the NAD+ angle, the fat-cells-that-burn-instead-of-store pitch

Caffeine intake should be limited to under 200 mg per day, and methylcobalamin requirements may rise, warranting individualized assessment