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This phenomenon was first described by Lemasters group [37] when APAP-induced MPTP opening and necrotic cell death in primary isolated hepatocytes was attenuated by MPTP inhibitors at early time points but not late time points where caspase activation was detected

Lai YL, Chang HH, Huang MJ, Chang KH, Su WH, Chen HW, et al

[3] Involved airways (bronchi) become enlarged and thus less able to clear secretions

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