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Key Points to Understand: Association, Not Causation: Some observational studies have suggested a link or association with frequent or prolonged use of acetaminophen during pregnancy

3.4.3 Mechanistic insights from preclinical modelsbarrier, immune, and neurotransmitter changes Rodent models of PTSD provide causal evidence that psychological trauma disrupts the MGBA, leading to microbiota alterations, compromised gut barrier integrity, immune activation and neurotransmitter imbalance

108 By enhancing therapeutic efficiency and potentially reducing treatment costs, rectal delivery is particularly promising for long-term disease management

Limited human observations corroborate a favorable short-term tolerability profile, usually involving mild, transient reactions such as localized injection-site irritation or temporary gastrointestinal discomfort