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Moreover, as a rate-limiting enzyme, GCLC catalyzing activity is subject to feedback inhibition by GSH [11], and abnormal expression is closely related to tumor progression and drug resistance in different histological types of human cancers [12, 13]

Acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for 56,000 emergency room visits per year

Collagen production and tissue remodeling processes reach their full expression