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And in the intestinal stem cells isolated from the uninjured and regenerating intestines, IGF1 increases the quantities of Sox9-Low and Sox9-High cells and the percentage of these cells in M-phase (Van Landeghem et al., 2015)

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Research has focused on its facilitation of synapse formation via HGF/Met receptor signalling, with investigations suggesting neurotrophic potency orders of magnitude greater than BDNF in dendritic branching assays

3g), suggesting that selected compounds foster NPC differentiation towards the oligodendroglial fate, with Sm9 and Sm11 also showing a positive effect on neurogenesis (Fig