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Preclinical studies have examined how MOTS-c influences AMPK pathway activation, insulin sensitivity in skeletal muscle tissue, and metabolic flexibility across multiple animal model systems

Free energy calculations To compute the free energy using the Molecular Mechanics Generalized Born Surface Area (MMGBSA) method, we chose 400 snapshots from the 200 ns Molecular Dynamics (MD) simulation dataset, spaced by every 5th snapshot and spanning frames 18,000 to 20,000

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Typically, non-photochemical quenching (NPQ) is regarded as one of the quickest mechanisms for modulating light harvesting, playing a crucial role in protecting PSII reaction centers from photodamage, which can lead to photoinhibition