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217 This promotes the migration of myeloperoxidase (MPO) and neutrophil elastase (NE) to the nuclear envelope, where NE partially degrades histones, leading to chromatin decondensation and the release of neutrophil extracellular traps (NETs)

5,8 Water-soluble antioxidants, such as vitamin C can be found in cellular fluids like cytosol and cytoplasmic matrix, whereas vitamin E, lipoic acid, and carotenoids are lipid-soluble antioxidants and are mostly found in a cellular membrane