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Phosphodiesterase 4 inhibitors for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs

Where the Cardiovascular Concerns Originated Early concerns about TRT and heart disease were driven by studies that had important limitations: Inclusion of frail or acutely ill men Use of high or inconsistent doses Lack of standardized monitoring Short follow-up periods Some studies grouped together men receiving physiologic replacement with those exposed to supraphysiologic levelstwo very different clinical scenarios

Rev 30, 200230 (2021)

This protocol is built for men already established on stable testosterone replacement therapy