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Importantly, RH-F/C-NPs markedly upregulated barrier-associated proteins including occludin, claudin-1, and ZO-1, underscoring their therapeutic potential for epithelial injury repair (194197)

[115] The decision to use ondansetron in these circumstances requires careful individualized risk-benefit assessment and thorough discussion of available alternatives

Moreover, these promising preclinical findings need to be translated into clinical practice, which faces several challenges, such as determining the optimal doses to be used, enhancing the bioavailability of the molecule, ensuring that its safe to be used for the long term, and understanding the response of the molecule in different patients, which are considered critical for effective therapy design

For the inward-occluded conformation of both the apo and P4S-bound hTauT, non-uniform refinement followed by local refinement with the soft mask covering hTauT was used to obtain final maps with resolutions of 2.8