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10.1038/s41419-024-07244-x Cell Death Dis

found that ferroptosis in ectopic endometrial stromal cells in patients with ovarian endometriosis could activate the p38 mitogen-activated protein kinase (p38 MAPK)/signal transducer and activator of transcription (STAT) 6 signalling pathway, thereby promoting local upregulation of vascular endothelial growth factor A (VEGFA) and interleukin-8 (IL-8) in ectopic lesions [15]

Conclusion: The PNPLA3 I148M oe reprograms macrophage metabolism because of reduced mitochondria number and/or mitochondrial dysfunction, thus affecting their phagocytotic capacity