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Research suggests MOTS-c may mimic effects of exercise by activating AMPK pathways

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Moreover, in a lung cancer mouse model, the peptide N-acetylglucosaminyltransferase 3 suppressed AKT phosphorylation triggered by c-MET, leading to decreased synthesis of the chemokine CXCL3, which is essential for MDSC attraction [82]

Despite these efforts, the technique still suffers from limited depth sensitivity, which is crucial for instance in measurements of the cerebral hemodynamics, limiting its translation to the clinics