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Our previous research showed that hepsin / mice exhibited decreased HGF-cMet signaling, with reduced levels of activated HGF and phosphorylated cMet, resulting in a two-fold increase in GJ expression compared to wild-type mice (Hsu et al

Future studies should employ human dermal fibroblast (HDF) or keratinocyte models to determine whether L-theanine directly modulates AGEs-RAGE signaling, NF-B activation, or MAPK phosphorylation under oxidative stress

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ZH11 was transformed with constructs pCAM2300: OsLIKE1 and CRISPR-Cas9: OsLIKE1 with Agrobacterium tumefaciens -mediated transformation at EDGENE BIOT (Wuhan, China)