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[71] also reported that the activation of STAT3 enhanced the FoxO-dependent expression of inhibitor of B (IB) proteins which induced the accumulation of NF-B complexes into cytoplasm, inhibiting the pro-inflammatory NF-B-dependent gene expression

Beyond skin aging, GHK-Cu's fibroblast-protective effects under radiation exposure have made it a compound of interest in radiobiology research, and separate literature has explored copper peptides in the context of skin regeneration alongside investigations into anti-cancer cellular signaling