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While these legal requirements protect end-users, they can meaningfully constrain market expansion

AMT lacks receptor specificity, which increases the off-target distribution 118,119

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Because sulfoxide metabolites are more potent nephrotoxicants than their parent S -conjugates, more research is needed on the extent of formation of S -(1,2-dichlorovinyl)-L-cysteine and N -acetyl- S -(1,2-dichlorovinyl)-L-cysteine sulfoxides by human tissues (liver and kidney), the extent to which these reactions occur in vivo, the enzymes involved, and their interindividual variability, including the role of genetic polymorphisms