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(7) Sarah Wrigley, Donia Arafa, and Daniela Tropea (2017) Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging Frontiets in Cellular Neuroscience, 2017 Feb 1, Volume 11, Page 14

It is an extremely complicated process where a lot of internal and external factors are involved in both steps (Drubin et al., 1985

Case studies demonstrating successful resolution of reactive metabolite liabilities are abundant in the medicinal chemistry literature and often involve the following strategies: (a) removal of the functional group susceptible to bioactivation, (b) modulation of electronic character (e.g